Pharmacokinetics of flunixin meglumine in dogs

Hardie, E.M.; Hardee, G.E.; Rawlings, C.A.

American Journal of Veterinary Research 46(1): 235-237


ISSN/ISBN: 0002-9645
PMID: 3970431
Document Number: 101
The pharmacokinetics of flunixin meglumine, a potent nonsteroidal anti-inflammatory agent, were studied in 6 intact, awake dogs. Plasma samples were obtained up to 12 hours after i/v administration. Distribution half-life was 0.55 hour; elimination half-life was 3.7 hours; volume of distribution (area) was 0.35 litres/kg; volume of distribution at steady state was 0.18 litres/kg; volume of the central compartment was 0.079 litres/kg; and total body clearance was 0.064 litres/kg. Flunixin concentrations obtained over a 6-hour period in 3 dogs with septic peritonitis did not differ from those obtained from healthy dogs.

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Pharmacokinetics of flunixin meglumine in dogs