Pharmacokinetics and effects of xylazine (Rompun) in dogs
Rector, E.; Otto, K.; Kietzmann, M.; Nolte, I.; Lehmacher, W.
Berliner und Munchener Tierarztliche Wochenschrift 109(1): 18-22
1996
ISSN/ISBN: 0005-9366 PMID: 8593154 Document Number: 461770
Six beagle dogs were treated with xylazine hydrochloride (1 mg/kg i.m.). The plasma xylazine concentration was measured by HPLC. Additionally, clinical effects were registered (cardiac rate, respiratory activity, electrocardiogram, body temperature, motoric activity, attention, analgesia). Maximum plasma concentrations were measured after 15 minutes (476 ng/ml). The plasma half-life was 24 minutes. Sedation was registered over one hour (xylazine concentration of more than 150 ng/ml). Within the first 30 minutes after treatment (xylazine concentration of more than 300 ng/ml), a low-grade analgesia was observed. In contrast, cardiac and respiratoric depression and also significantly diminished body temperature were registered over 2 to 3 hours.