Cardiopulmonary effects of xylazine in dogs
Klide, A.M.; Calderwood, H.W.; Soma, L.R.
American Journal of Veterinary Research 36(7): 931-935
1975
ISSN/ISBN: 0002-9645 PMID: 1147358 Document Number: 83831
Effects of xylazine were determined on arterial pH, arterial oxygen pressure (Pao2), arterial CO pressure (Paco2), aortic blood pressure, aortic flow, heart rate, pulse pressure, stroke volume, and peripheral resistance of dogs. The drug was given i/v with and without atropine and was given i/m without atropine. After i/v administration of xylazine (1.1 mg/kg), arterial pH, Pao2, and Paco2 values were unchanged from control values. However, the drug did produce a significant decrease in heart rate, decrease in aortic flow, initial increase in blood pressure followed by decrease, and increase in peripheral resistance. Stroke volume and pulse pressure were not significantly changed. Atropine (0.02 mg/kg i/v) did not significantly change any of the effects produced by xylazine. I/m administration of xylazine (2.2 mg/kg) did not produce significant changes in arterial pH, Pao2, or Paco2. Heart rate and aortic flow decreased significantly, but significant changes did not occur in aortic blood pressure or peripheral resistance; however, the changes in these last two values were in the same direction and were of similar magnitude as those following i/v administration of xylazine.