Role of phagocytes and antibodies in freeing the body from influenza virus
Kosiakov, P.N.; Lazarenko, V.N.; Rovnova, Z.I.
Voprosy Virusologii 1: 66-70
1976
ISSN/ISBN: 0507-4088 PMID: 1258457 Document Number: 99469
Persistence of influenza virus in normal and immune mice was studied by determinations of the virus infectivity and by the immunofluorescence procedures. After intraperitoneal inoculation the virus could be found in macrophages of the peritoneal exudate in both normal and immune animals. However, in macrophages of normal mice synthesis of V- and S-antigens of influenza virus occurred indicating the possibility of virus reproduction in them, whereas in macrophages of immune animals there was practically no synthesis of S-antigen despite a greater number of cells with V-antigen of influenza virus in their cytoplasma. The assumption that elimination of influenza virus from the body is due to specific antibody and immunologically changed macrophage elements is substantiated.