Comparative clinical electroencephalographic study of cycloserine and terizidon tolerance
Shmelev, N.A.; Shabalova, L.N.; Kolosovskaia, V.P.
Antibiotiki 20(2): 174-180
1975
ISSN/ISBN: 0003-5637 PMID: 1091207 Document Number: 94117
The aim of the study was comparative investigation of cycloserin and terizidone tolerance by patients with the lung tuberculosis. The investigation procedure included parallel clinical observations and electroencephalographic studies (EEG) using light and sonic stimulation. Sixty six and 26 patients treated with cycloserin and terizidone respectively were observed. The results of the studies showed that by the mechanism of their action on the central nervous system terizidone and cycloserine were similar and increased the general reactivity of the brain. However, terizidone promoted an increase of the activating effect of the ascending part of the reticular formation of the brain stem to a lesser extent than cycloserine. Terizidone in a dose of 0.25 g 3 times a day was well tolerated by the patients with concomitant psycho-neurological impairements.