Thymus influence on the conversion of 19S to 7S antibody formation in the response to TNP-Brucella
Romano, T.J.; Thorbecke, G.J.
Journal of Immunology 115(2): 332-334
1975
ISSN/ISBN: 0022-1767 PMID: 807631 Document Number: 93321
Serially transferred LAF1 spleen cells show a deficient 7S PFC response to TNP-Brucella when thymectomized mice (Tx) as compared to normal irradiated intermediate hosts are used. This defect can be corrected by combining the spleen cells with lymph node cells from the Tx intermediate hosts. It is concluded that T helper cells, residing primarily in lymph node, are needed for efficient 19S to 7S conversion in the immune response.
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