Splenopentin--influence on antibody formation in immunosuppressed animals and on phagocytic capability of human granulocytes
Diezel, W.; Eckert, R.; Müller, G.M.; Forner, K.; Sönnichsen, N.
Archiv für Geschwulstforschung 59(3): 161-164
1989
ISSN/ISBN: 0003-911X PMID: 2667491 Document Number: 337198
Sublethally x-ray irradiated C57 Bl/6 Bln. mice (whole body irradiation with 600 cGy) were treated with or without a splenopentin derivative (DA SP-5: N alpha-acetyl-L-arginyl)-(N alpha-acetyl-L-lysyl)-L-glutamyl-L-valyl-L-tyrosine and compared for their capacity to produce antibodies against target sheep red blood cells. As demonstrated DA SP-5 treated mice produced antibodies earlier and in a higher level than animals untreated. Furthermore, DA SP-5 influences the phagocytic capability of human granulocytes in a dose dependent matter.