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Investigation of the influence of copper and cobalt ions on the carcinogenesis by diethyl-nitrosamine (DENA) in Wistar rats

Zeller, W.J.

Archiv für Geschwulstforschung 45(7): 634-636

1975

ISSN/ISBN: 0003-911X
PMID: 818977
Document Number: 93151
Simultaneous subcutaneous applications of metal salts (CuSO4X 5H2O and CoC12 X 6 H2O respectively) have no influence on the percentage of the tumor yield after long-term subcutaneous applications of diethylnitrosamine (DENA). In accordance with results in syrian golden hamsters a high percentage of tumors of the nasal cavity (predominantly esthesioneuroepitheliomas) occur after subcutaneous injection of DENA into rats, too.

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