Influence of fasting period, ligation time, sex, age and bodyweight on the gastric secretory response of pylorus-ligated Wistar rats
Schiantarelli, P.; Toson, G.; Guelfi, M.; Murmann, W.
Arzneimittel-Forschung 28(7): 1127-1130
1978
ISSN/ISBN: 0004-4172 PMID: 582701 Document Number: 129317
A study on variables influencing the gastric secretory response of pylorus-ligated Wistar rat, shows that: 1. 24 h is a sufficient fasting period for satisfactory emptying of the stomach, periods of up to 48 h yielding no advantage; 2. between 2 and 4 h is the most appropriate pyloric ligation time because in this range there are no variations in volume of gastric secretion, concentration and output of acid per unit of ligation time; 3. sex has no influence on any of the parameters; 4. animals should be age-selected because only above a given age threshold the gastric secretory response per unit of bodyweight is constant.