Inhibition of rat serum polyphenoloxidase activity by silver ions abolished by administration of copper ions

Pribyl, T.; Schreiber, V.; Jahodová, J.

Folia Biologica 26(1): 47-52

1980


ISSN/ISBN: 0015-5500
PMID: 7364132
Document Number: 162954
The administration of silver nitrate (6.47 mg, i.e. 60 mumol Ag+/rat/day) in food was followed in only two days by a pronounced decrease in polyphenoloxidase activity (ceruloplasmin) in rat serum. The administration of copper in the form of copper sulphate (12.7 mg, i.e. 200 mumol Cu2+/rat/day) raised polyphenoloxidase activity (the ceruloplasmin level), the increase being particularly marked on the first four days. On combining the two factors, the effect of Cu+ predominated throughout the duration of the experiment (32 days).

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