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Enhancement of intestinal sucrase activity in experimental diabetes: the role of intraluminal factors

Olsen, W.A.; Korsmo, H.

Journal of Laboratory and Clinical Medicine 85(5): 832-837

1975

ISSN/ISBN: 0022-2143
PMID: 123549
Document Number: 93079
Male Holtzman rats were made diabetic by intravenous injection of streptozotocin 3 weeks after construction of Thiry-Vella loops. Five days later sucrase activity was measured in the excluded segment and in the proximal jejunum. Exclusion alone resulted in a 77% decrease in mucosal protein content without change in sucrase specific activity, indicating simply that the number of mucosal cells had diminished. Diabetes increased sucrase specific activity from 0.643 mu mole/mg protein min to 0.1074 in the proximal jejunum and from 0.0467 to 0.1040 in the excluded segment.

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