Antioxidant activity of the hepatoprotector maxar in experimental diabetes
Ian'kova, V.I.; Ivanova, I.L.; Fedoreev, S.A.; Kulesh, N.I.
Eksperimental'naia i Klinicheskaia Farmakologiia 65(4): 33-36
2002
ISSN/ISBN: 0869-2092 PMID: 12452131 Document Number: 548175
Maxar, a hepatoprotector of plant origin containing polyphenols, exhibits an antioxidant effect in animals with alloxane-induced diabetes. The administration of maxar reduces the intensity of lipid peroxidation (LPO) and normalizes the level of LPO products (diene conjugates, malonic dialdehyde, Schiff bases) in liver. The drug produces regulation of the protective antioxidant system primarily by increasing the level of endogenous antioxidants via activation of the glutathione-dependent enzymatic mechanisms and detoxication of lipid hydroperoxide radicals.