The antioxidant activity of cyclohistidylproline
Shvachkin, I.P.; Korshunova, G.A.; Bavykina, N.I.; Guliaeva, N.V.; Dupin, A.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 108(12): 671-673
1989
ISSN/ISBN: 0365-9615 PMID: 2634436 Document Number: 330293
A cyclohistidyl-proline, cyclopeptide possessing a hormonal and neurotrophic activity is shown to be an inhibitor of the (Fe + ascorbic acid)-induced peroxidation of membrane lipids, its effect being dependent on its concentration. Inhibition of the malondialdehyde formation by cyclohistidil-proline is accompanied by protection of the membrane bound Ca-pump. In the test of the free radical cumole oxidation antioxidative effect of cyclohistidyl-proline is 4 times higher than that of the hydrophilic antioxidant carnosine. After peritoneal injection of cyclohistidil-proline (15 mg/kg of body weight) to rats the stationary level of thiobarbituric acid reactive products in rat brain or serum is pronouncedly decreased, this effect being in progress up to 6 h after injection. Antioxidative action of cyclohistidyl-proline suggests to be on the basis of a variety of its biological effects.