Cardiovascular and hemodynamic effects of derivatives of metoclopramide
Mouillé, P.; Cheymol, G.
Archives Internationales de Pharmacodynamie et de Therapie 215(1): 139-149
1975
ISSN/ISBN: 0003-9780 PMID: 1156043 Document Number: 93078
Two salicylamides, thiapride and sultopride, were found to provoke a dose-related depressor effect in the anesthetized dog. This effect was qualitatively similar to that of procaïnamide and metoclopramide. The hypotensive and negative inotropic effects were not related to the parasympathic system. In fact these compounds are weak autonomic antagonists. They do not exert any anticholinesterase activity. Intra-arterial administration provoked vasodilation.