Changes in imipramine induced noradrenaline potentiation by varying activity of gastric juice under oral medication
Fischbach, R.
Arzneimittel-Forschung 25(1): 123-131
1975
ISSN/ISBN: 0004-4172 PMID: 238541 Document Number: 92732
From the serial studies on imipramine dependent noradrenaline (NA) rise at different values of gastric acid with 336 registrations of blood pressure, it follows that a lawful relation exists between imipramine absorption and gastric juice acidity. At pH values of 3.5--6.0 a distinct decreased absorption of orally supplied imipramine was stated. After changing the pH value by acid substitution, a full absorption is reached. This state seems to be of special practical importance in the treatment of depression with thymoleptics.