Carcinoembryonic antigen and immunoglobin in gastric juice in the diagnosis of gastric cancer
Wang, Y.M.; Zheng, J.J.; Ren, G.R.; Gong, Z.L.; Huang, F.Z.; Xue, L.S.; Jiang, J.H.; Zhu, X.S.; Wu, R.Y.; Ling, K.
Zhonghua Zhong Liu Za Zhi 8(4): 270-272
1986
ISSN/ISBN: 0253-3766 PMID: 3757741 Document Number: 274053
Levels of carcinoembryonic antigen (CEA) and immunoglobin (Ig) in gastric juice of 93 patients with benign and malignant gastric diseases were assayed. The CEA level in gastric cancer patients (55.73 .+-. 38.26 ng/ml) was obviously higher than that in peptic ulcer (15.51 .+-. 12.09 ng/ml) and superficial gastritis (26.96 .+-. 20.17 ng/ml). But no significant difference was found between the CEA levels of gastric cancer and chronic atrophic gastritis (48.66 .+-. 31.87 ng/ml). Also, elevated CEA was closely correlated to intestinal metaplasia. The positive rate of Ig was significantly higher in gastric cancer (IgG .gtoreq. 185 .mu.g/ml, IgA .gtoreq. 100 .mu.g/ml) than in benign gastric diseases. Although no correlation is present in the CEA and Ig in gastric juice, the combination of these two methods could improve the diagnostic accuracy. We believe that the two assays are worthy for screening gastric cancer from patients with high risk, and for identifying precancerous lesions.