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Changes in the rat gastric mucosa after intragastric administration of gastric juice from healthy controls and from patients with duodenal ulcer

Amirov, N.Sh.; Belostotskiĭ, N.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 94(11): 17-19

1982

ISSN/ISBN: 0365-9615
PMID: 7150727
Document Number: 187156
It has been shown in rat experiments that gastric juice from duodenal ulcer patients possesses significantly greater aggressiveness as regards the gastric mucosa of rats as compared to gastric juice from normal subjects. Injuries to the gastric mucosa of rats under the experimental conditions were consequent, apart from the injuring action of exogenic proteases of the patients' gastric juice, on activation of the system of mucosal proteases active in a weak-acidic medium (lysosomal), as well as on the decreased resistance of rat gastric mucosa proteins to the destruction by rat gastric mucosa pepsins under acidic pH values. The impairment of the mucosal resistance to the destruction might be promoted by the reduced number of glycosaminoglycan fractions, detected during electrophoresis of the mucosal extracts from the experimental rats.

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