Acetylsalicylic acid-induced biochemical changes in gastric juice: a failure of adaptation?
Nain, C.K.; Kaur, U.; Singh, V.; Dhawan, V.; Singh, K.
Indian Journal of Gastroenterology Official Journal of the Indian Society of Gastroenterology 17(1): 4-5
1998
ISSN/ISBN: 0254-8860 PMID: 9465503 Document Number: 494524
Acetylsalicyclic acid (ASA) causes gastric mucosal damage which diminishes with continued use due to adaptation. To determine the net effect of these processes on the gastric juice, we estimated acid, osmolality, bicarbonate concentration in nonparietal gastric juice, calcium, potassium and sodium in 18 patients (9 men; mean age 32 years, range 20-46) with irritable bowel syndrome, before and after 600 mg of ASA taken post-cibum thrice daily for 4 weeks. Osmolality was determined by an osmometer, acidity by titration, and Na+, K+ and Ca++ using a sodium-potassium-calcium analyzer; bicarbonate was derived from the two-component model of Feldman. Gastric juice K+ and Na+ increased significantly from mean (SE) 14.6 (0.5) and 197.5 (16.3) to 16.7 (0.4) and 256.8 (18.1) mEq/L, respectively. The other parameters remained unchanged. After four weeks of ASA ingestion there is a dichotomy of gastric mucosal injury and adaptation, with preservation of acid secretion but continued loss of Na+ and K+.