Consequences of the chronic administration of phenformine on the blood thiamine level in the dog
Valette, G.; Ribes, G.; Loubatieres-Mariani, M.M.; Loubatieres, A.L.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 169(6): 1562-1567
1975
ISSN/ISBN: 0037-9026 PMID: 132248 Document Number: 91878
The chronic oral administration of phenformin (20 mg/kg daily during 8 days) to the normal concious dog provokes a decrease in the fasting thiamine levels of plasma and erythrocytes. During intragastric loading tests with thiamine hydrochloride (30 mg/kg), carried out during the chronic treatment with the biguanide, the curve of plasma hyperthiaminemia is increased. The authors suggest an explanation for these apparently contradictory results.