Lactic acidosis after administration of guanidine derivatives (buformine, phenformine)
Butt, H.; Reitinger, J.
Medizinische Klinik 72(16): 708-711
1977
ISSN/ISBN: 0025-8458 PMID: 857140 Document Number: 112353
Three patients are reported on, who at the time of admittance showed a decompensated metabolic acidosis, elevated concentrations of serum lactate and a reduced kidney funktion. All the patients had taken guanidine derivates (phenformine, buformine) because of diabetes mellitus. The serum biguanid concentrations, however, were elevated in only two cases. Therapy of the lactic acidosis has to be directed at the underlying disease. In biguanid incluced acidosis, haemodialysis with simultaneous administration of sodium bicarbonate is indicated.