Lactic acidosis, hyperamylasemia, and phenformin
Greco, A.V.; Ghirlanda, G.; Bianco, A.
Minerva Medica 83(12): 777-783
1992
ISSN/ISBN: 0026-4806 PMID: 1283446 Document Number: 401206
Phenformin is still used in the therapy of non-insulin dependent diabetes in association with sulphonylureas. The controindications to the use of this drug often are not kept in due consideration. It is therefore often possible to observe cases of irreversible lactic acidosis with lethal outcome. In this paper, three cases of lactic acidosis from phenformin administration are reported. Some characteristics of this clinical picture are underscored: accompanying ketoacidosis, hyperamylasemia. On the basis of their observation, the Authors conclude that those diabetic patients who can be treated with diet alone or with diet and sulphonylureas must not be treated with phenformin. Metformin is then proposed as a more flexible and safer drug.