Thiamine diphosphate level and metabolism in allergic myocarditis and treatment with peloid
Leus, N.F.
Voprosy Meditsinskoi Khimii 32(1): 119-122
1986
ISSN/ISBN: 0042-8809 PMID: 3953005 Document Number: 272417
Enzymatic systems involved in thiamin metabolism were studied in experimental allergic myocarditis. Development of inflammation in myocardium was accompanied by a distinct activation of thiamin pyrophosphatase which catalyzed the most important step responsible for deterioration of the coenzyme functions. The stabilizing effect of peloid on the intracellular pool and compartmentalization of thiamin in myocarditis involved equilibration of the anabolic and catabolic reactions in the coenzyme metabolism, mainly due to selective inhibition of the thiamin pyrophosphatase activity stimulated under these conditions.