Allergic myocarditis in clozapine treatment
Jensen, V.E.; Gøtzsche, O.
Ugeskrift for Laeger 156(28): 4151-4152
1994
ISSN/ISBN: 0041-5782 PMID: 8066913 Document Number: 423205
Clozapine is a high-dose neuroleptic, which is recommended only for those cases in which patients have failed to respond adequately to standard antipsychotic drugs. This report describes a 45 year old man with ischaemic heart disease who died of cardiogenic shock 11 days after starting treatment with clozapine. Autopsy showed apart from coronary atherosclerosis and interstitial fibrosis a considerable infiltration of eosinophilic granulocytes in the myocardium suggesting myocarditis as the cause of death.