The effect of hormones regulating calcium metabolism on the growth and metastasis of experimental tumors
Kashulina, A.P.; Saraeva, Z.M.; Tereshchenko, I.P.; Golovanov, M.V.; Briskin, A.I.
Voprosy Onkologii 21(5): 87-91
1975
ISSN/ISBN: 0507-3758 PMID: 1108436 Document Number: 90795
Injection of parathormone and thyrocalcitonin into rats with DMBA induced sarcomas resulted in a considerable stimulation of the metastasization process. It was found that the level of total Ca++ in tumor tissue was reduced under the influence of PTH. Under conditions of chronic exogenous hyperparathyroidism autoimmunereactions were suppressed. A prolonged administration of TCT did not alter considerable the total Ca++ content in tumor and markedly activated the autoantibody production in immunocompetent cells.