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Effect of three retinoids on the growth of experimental tumors

Nozdrin, V.I.; Samokhvalov, G.I.; Zhidkova, T.A.; Poliachenko, L.N.; Vakulova, L.A.

Voprosy Meditsinskoi Khimii 32(4): 133-136

1986

ISSN/ISBN: 0042-8809
PMID: 3765491
Document Number: 276810
Influence of retinoid C17-diester, retinyldimedone and L-tocopherylretinoate on the growth of transplanted tumors was investigated in F1(C57B1/6 .times. CBA) strain of mice. The retinoids studied proved to be less toxic than retinoic acid. Both retinoid C17-diester and L-tocopherylretinoate reduced growth of cervical cancer, while retinyldimedone inhibited growth of Lewis carcinoma (lung tumor) and of stomach carcinoma.

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