Effect of chemotherapy on the nucleoside phosphate kinase activity in experimental tumors
Tret'iakov, A.V.; Filov, V.A.
Voprosy Onkologii 32(11): 95-98
1986
ISSN/ISBN: 0507-3758 PMID: 3024413 Document Number: 270715
In animals with experimental transplantable tumors, an effective treatment with antitumor compounds brought about interrelated changes in nucleoside phosphate kinase activity. The decrease in thymidine phosphate kinase activity was as a rule matched by an increase in that of uridine phosphate kinase. Consequently, "thymidine kinase-uridine kinase" shunt responsible for thymidine-uridine interconversion was suggested, which is switched on when the homeostasis of tumor cells is disturbed. In treatment of tumor-bearing animals, the effective dosage of antitumor drugs was considerably decreased due to a combination of the said compounds (inhibiting nucleoside kinases) or with azauridine which inhibits uridine monophosphate synthesis from orotidine-5'-phosphate.