Effect of chemical hepatic carcinogens and noradrenaline on the nucleoside phosphokinase activity of liver cells
Gurkalo, V.K.; Tret'iakov, A.V.
Voprosy Meditsinskoi Khimii 25(5): 540-543
1979
ISSN/ISBN: 0042-8809 PMID: 227170 Document Number: 153946
Distinct increase in activity of uridine kinase and pronounced decrease in thymidine kinase activity were observed in cell-free extracts of rat liver tissue at early stages of hepatocarcinogenesis caused by administration of N-nitrose diethylamine and 2-acetyl aminofluorene. Exogenous noradrepaline did not affect the altered activity of thymidine kinase but stimulated the effect of N-nitrose diethylamine and lowered the effect of 2-acetyl aminofluorene on the urindine kinase activity. Adrenergic neurotransmitters appear to influence the cell proliferation due to modification of the enzymes participating in the synthesis of nucleic acid precursors.