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Transformation of BHK 21/13 cells by chemical carcinogens and mutagens

Altanerová, V.

Neoplasma 22(6): 599-606

1975

ISSN/ISBN: 0028-2685
PMID: 55982
Document Number: 89736
In vitro transformation of BHK 21/13 cells by chemical carcinogens is reported. The hamster cells were treated with MCA, BP, 4-NQO and 5-azaCR at various concentration and duration of treatment. The morphological, karyological and growth characteristics of cell lines were investigated. Search for RNA tumor viruses in transformed cells using 3H-uridine labeling, detection of DNA polymerases, electron microscopy investigations failed to detect presence of C-type virus particles.

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