Molecular analysis of mutations induced by chemical carcinogens in mammalian cells. I. the use of selectable gene loci
Fortini, P.; Dogliotti, E.
Annali Dell'istituto Superiore di Sanita 30(2): 183-190
1994
ISSN/ISBN: 0021-2571 PMID: 7832409 Document Number: 433926
Several lines of evidence indicate the important role of mutation in the process of carcinogenesis, however our understanding of the factors that influence the formation of mutation is still limited. Recent developments in the analysis of gene mutations at selectable loci in cultured mammalian cells has allowed to accumulate a significant amount of information on the type and distribution of mutations induced by a variety of chemical and physical agents. The purpose of this review is to summarize the data relative to chemical carcinogens and to discuss how their mechanism of interaction with DNA and the repair processes active on the induced lesions affect mutational spectra.