Effect of nitroglycerin on the calcium mechanism regulating the tonus of large and small coronary arteries
Shishkin, S.B.; Baranov, A.G.
Farmakologiia i Toksikologiia 47(1): 50-53
1984
ISSN/ISBN: 0014-8318 PMID: 6323214 Document Number: 240049
It has been established in experiments on isolated ring-shaped strips of large and small coronary artery of the dog that nitroglycerin produces a more pronounced and prolonged relaxation of the myocytes of large coronary arteries at the expense of the inhibition of transmembranous transport and intracellular exchange of calcium ions. In small coronary arteries, nitroglycerin inhibits transmembranous transport of calcium ions, exerting no antagonistic effect on the exchange of intracellular calcium ions. Thus, the different effect of nitroglycerin on the tone of large and small coronary arteries is accounted for by different sensitivity to the drug action of the depot of intracellular calcium ions in the myocytes of these objects.