Mechanism of action of naphthoquinones and hydroxycoumarins on the mechano-active properties of isolated coronary arteries
Lider, V.A.; Shishkin, S.B.; Feofilaktova, S.N.
Farmakologiia i Toksikologiia 50(5): 31-34
1987
ISSN/ISBN: 0014-8318 PMID: 3691774 Document Number: 293242
The action of natural naphthoquinones and their antagonists oxicoumarins on mechanoactive properties of isolated coronary arteries was studied in experiments on male albino rats. Vitamin K deficiency (primary, secondary) was found to be accompanied with disturbances of mechanoactive properties of the heart vessels Naphthoquinones (vitamins K1 and K3) exerted a spasmolytic action on coronary vessels of intact animals and animals with vitamin K deficiency as well. These effects are supposed to be probably related to the redistribution of cations Ca2+ and K+ in membranes.