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Role of active vitamin D3 metabolites in regulating calcium metabolism in rats during hypokinesia

Sergeev, I.N.; Afonin, B.V.; Blazheevich, N.V.; Morukov, B.V.; Belakovskii, M.S.

Kosmicheskaia Biologiia i Aviakosmicheskaia Meditsina 19(6): 46-50

1985

ISSN/ISBN: 0321-5040
PMID: 3003454
Document Number: 254601
The rats exposed to prolonged hypokinesia showed hypocalciemia, lower PTH and higher calcitonin concentrations in the serum, decreased calcium absorption in the small intestine, and a trend toward nephro- and arteriocalcinosis. Prophylactic administration of 24,25-hydroxy D3. 1,25-hydroxy D3 and their combinations enhanced calcium absorption and alleviated hypocalciemia. The changes in the hormonal regulation of calcium homeostasis can be viewed as a factor responsible for calcium metabolic disorders associated with hypokinesia.

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