Delta-9 -tetrahydrocannabinol and decreased macrophage migration inhibition activity
Gaul, C.C.; Mellors, A.
Research Communications in Chemical Pathology and Pharmacology 10(3): 559-564
1975
ISSN/ISBN: 0034-5164 PMID: 1135516 Document Number: 87258
Delta-9-Tetrahydrocannabinol (0.31 mg - 1.25 mg per kg body weight) given to immunized rats by intraperitoneal injection depresses the activity of macrophage migration inhibition factor. The lowest levels of activity in peritoneal exudates were observed 15 hours after the injection of cannabinoid. This decreased activity may be related to the impaired cellular immunity observed in regular users of cannabis.
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