Production in vivo of macrophage migration inhibition and stimulation factors in the inductive phase of the alloimmune response
Suslov, A.P.; Iazova, A.K.; Berkova, N.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 102(7): 66-68
1986
ISSN/ISBN: 0365-9615 PMID: 3524704 Document Number: 272608
Macrophage migration inhibition and stimulation factors were revealed in the serum of alloimmune mice by polyacrylamide gel electrophoresis. CBA mice were primed intravenously with 90 X 10(6) and challenged subsequently intravenously with 20 X 10(6) spleen cells of BALB/c mice. Macrophage migration inhibition and stimulation factors were revealed in pre- and post-albumin fractions, respectively, already on days 1 and 6 after alloimmunization. It is suggested that at an early phase of immune response the immunomediators with alternative functions whose local activity gradients predetermined the macrophage behaviour, are released into the serum of alloimmune animals.