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Hydrolysis of 11-palmitoyloxy-delta 9-tetrahydrocannabinol to 11-hydroxy-delta 9-tetrahydrocannabinol by cholesterol esterase and a lipase

Leighty, E.G.

Research Communications in Chemical Pathology and Pharmacology 24(2): 393-396

1979

ISSN/ISBN: 0034-5164
PMID: 461993
Document Number: 151108
11-Palmitoyloxy-delta 9-tetrahydrocannabinol (11-palm-delta 9-THC) has been identified in the rat in our laboratory as a long-retained metabolite of delta 9-tetrahydrocannabinol (delta 9-THC), the active component of marihuana (Leighty, 1973). Although it is not known as yet if 11-palm-delta 9-THC is itself psychoactive it could be hydrolyzed to active 11-hydroxy-delta 9-tetrahydrocannabinol (11-OH-delta 9-THC). Our in vitro studies show that cholesterol esterase and a lipase can hydrolyze 11-palm-delta 9-THC to 11-OH-delta 9-THC.

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