Anti-inflammatory Activities of Erythrina variegata Bark Ethanolic Extract
Thongmee, P.; Itharat, A.
Journal of the Medical Association of Thailand 99(Suppl 4): S166-S171
2016
ISSN/ISBN: 0125-2208 PMID: 29926696 Document Number: 8367
The bark of Erythrina variegata Linn.(Ev) is used in Thai traditional medicine for the treatment of many To study anti-inflammatory activities of ethanolic extract of E. variegata in vitro. Bark of E. variegata was extracted with 95% ethanol. In this study, Griess reagent was used to The ethanolic extract of E. variegata showed potent anti-inflammation properties by inhibiting prostaglandins production through enzyme COX-2 and inhibitory activity against lipopolysaccharide induced nitric oxide production in RAW 264.7 cell lines with an IC50 value of 9.27±0.72 and 47.1±0.21 μg/ml, respectively. However it was not effective against TNF-α release. The ethanolic extracts of E. variegata bark showed higher inhibitory effect on PGE2 as acute inflammation than inhibitory effect on Nitric oxide production and TNF-α release representing chronic inflammation. This study thus supports the use of E. variegata bark for treatment of inflammation-related diseases by Thai traditional medicine.