Anti-inflammatory, anti-nociceptive and antipyretic effects of the ethanol extract from root of Piper sarmentosum Roxb
Sireeratawong, S.; Vannasiri, S.; Sritiwong, S.; Itharat, A.; Jaijoy, K.
Journal of the Medical Association of Thailand 93(Suppl 7): S1-S6
2010
ISSN/ISBN: 0125-2208 PMID: 21298834 Document Number: 10976
Piper sarmentosum Roxb. (Cha Phul) is a plant in the Piperaceae family which the whole plant is used as an expectorant and the leaf as a carminative. Many extracts from the plants in this family show anti-nociceptive, anti-inflammatory and antipyretic activities in various animal models. To investigate the anti-inflammatory, anti-nociceptive and antipyretic effects of the ethanol extract from P. sarmentosum root. In vivo study. P. sarmentosum extract significantly inhibited ethyl phenylpropiolate-induced ear edema as well as carrageenan-induced hind paw edema in rats. The extract reduced transudative and granuloma weights of the chronic inflammatory model using the cotton pellet-induced granuloma formation in rats. The extract exerted a pronounced inhibitory activity on the early phase and late phase of the formalin test in mice. In addition, the extract elicited an antipyretic activity on yeast-induced hyperthermia in rats. P. sarmentosum extract possessed anti-inflammatory, anti-nociceptive and antipyretic activities.