The effect of bromantane on the erythro- and leukocytic profile of the peripheral blood in rats
Bugaeva, L.I.; Spasov, A.A.; Morozov, I.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 62(4): 40-43
1999
ISSN/ISBN: 0869-2092 PMID: 10513335 Document Number: 7780
The specific effect of bromantan on blood tissue is demonstrated in rats. In chronic injection in a dose of 30 mg/kg bromantan raised the level of hemoglobin and leukocytes. In doses of 150 and 600 mg/kg it increased at first (3 months) and then reduced the level of erythrocytes, hemoglobin, and leukocytes. Reversible poikilocytosis, granulocytosis, and agranulocytosis were encountered. Hyperchromatosis and hypertrophy of the hepatocytes were found in the tissues of the liver and hemosiderosis was discovered in the spleen. It is suggested that the blood tissue is a "target" in the toxic effect of bromantan.
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