Cytokines profile and metabolic activity of neutrophils of peripheral blood when progressing neoplasma
Abakumova, T.V.; Antoneeva, I.I.; Gening, T.P.; Gening, S.O.; Dolgova, D.R.; Fomina, A.V.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 4: 86-90
2014
ISSN/ISBN: 0031-2991 PMID: 25980232 Document Number: 672786
The neutrophil is considered as the peculiar monocelled sekretorny gland realizing the effector potential including by secretion of soluble products - cytokines and for today. Influence of a tumor on functional activity of neutrophils depends on type, localization and a stage of its development. In our research dynamics of metabolic and of neutrophils of peripheral blood, the contents in a lysate and serums of blood of cytokines of IL-1β, 1Ra, 2, 6, 10, 18, TNF-α, IFN-γ and is studied when progressing a cervical cancer. Cytokines and metabolism indicators - activity of, determined by an immunofermental method, level of cationic proteins, a share of active cages in the spontaneous NST-test were cytochemical. It is shown that when progressing cervical cancer against increase in total of neutrophils significant decrease in their, aerobic and anaerobic bacterial action, decrease in the IL-1β and IL-1 Ra level, and also IFN-γ takes place at TNF-α increase, increase of production of matrix metalloproteinas-2 on Ib-IIa of a stage of a disease that allows to assume emergence at this stage of cervical cancer of pro-tumoral effect of neutrophils.