Cytochemical examination of peripheral blood neutrophils of patients with hypothyroidism
Hrycek, A.
Wiadomosci Lekarskie 46(19-20): 736-740
1993
ISSN/ISBN: 0043-5147 PMID: 7975618 Document Number: 406461
In patients with primary hypothyroidism a decrease of activity of acid phosphatase and beta-glucuronidase and an increase of arylsulphatase activity were found in cytochemical investigations of peripheral blood neutrophils. In the group of patients a decrease was also observed of the value of indices of spontaneous and stimulated nitroblue tetrazolium reduction. In patients with primary hypothyroidism a number of abnormalities may develop manifesting themselves as changed outfit of the neutrophils with lysosomal enzymes, and weakening may occur in these cells of redox processes evaluated by the test with nitroblue tetrazolium. The presence of the above mentioned features in the neutrophils may be interpreted as a part of metabolic and functional disturbances in the tissues of various organs in patients with hypothyroidism.