Cytochemical study of peroxidase activity and the peroxidase-endogenous hydrogen peroxide system in the peripheral blood neutrophils of mice exposed to prodigiozan and retabolil
Golikov, I.V.; Lomonosov, V.A.; Danilova, L.P.; Govberg, I.I.; Rogovin, V.V.
Farmakologiia i Toksikologiia 45(4): 70-73
1982
ISSN/ISBN: 0014-8318 PMID: 7128792 Document Number: 191285
The paper concerns changes in the activity of some enzymes of azurophil granules of mouse neutrophils under a single administration of the bacterial polysaccharide prodigiosan and the synthetic anabolic hormone retabolil. Prodigiosan increases 1.4-fold the activity of the peroxidase-hydrogen peroxide system in azurophil granules of intact mice. In mice with leukopenia, prodigiosan normalizes the leukocyte count after 24 hours. At the same time there is an increase in the activity of peroxidase. It is assumed that under the effect of the same drug the cells of the animals in different physiological conditions may show an activation of the different components of antimicrobial defence. Retabolil raises the activity of peroxidase 96 hours after the first administration. Following 192 hours the activity reduces to normal and remains unchanged after the second drug administration.