Circumoval precipitin test in schistosomiasis mansoni. A study of 400 patients
Rodríguez-Molina, R.; Oliver-González, J.; Rivera-de Sala, A.
Boletin de la Asociacion Medica de Puerto Rico 58(4): 159-165
1966
ISSN/ISBN: 0004-4849 PMID: 5222460 Document Number: 700073
The circumoval precipitin test (CPT) was performed in blood sera from 400 individuals infected with Schistosoma mansoni and gave positive results in 368 (92%). The test was also performed in sera from 100 persons of this group before and after administration of variable amounts of Stibophen (Fuadin). Only about 11% of treated cases gave a negative CPT, although 45.7% of stools were negative. This may have been due to the known transitory supressive effect of stibophen. 100 other patients aparently not suffering from schistosomiasis had a negative CPT. Results indicate that the CPT is a reliable diagnostic tool, but at present it cannot be considered effective in appraising the efficacy of chemotherapy. Advantages and drawbacks of the test are discussed. Other investigations on problems related to serology of schistosomiasis are also discussed.