Oral supplementation of Thuja oreintalis leaf extract moderately affects the behavior in albino mice in a gender specific manner
Riaz, B.; Babar, R.Iftikhar.Khan.; Iqbal, S.; Ali, M.; Iqbal, F.
Pakistan Journal of Pharmaceutical Sciences 30(3): 683-688
2017
ISSN/ISBN: 1011-601X PMID: 28653910 Document Number: 693460
Present study was designed to demonstrate the effect ethanolic leaf extract of Thuja orientalis on the learning and memory formation in albino mice. Four week old albino mice were either orally supplemented with 50mg/ml solvent/Kg body weight of Thuja orientalis or with equal volume of saline solution (0.9% NaCl) for seven days. A battery of neurological tests (Elevated plus maze, Rota Rod, light and dark box, open field and novel object recognition test) were applied at the end of dose supplementation. Thuja orientalis leaf extract treated female mice spent significantly les time on rotating rod (P = 0.02) than male treated with saline solution . While all other neurological test performances varied non significantly (P > 0.05) when compared between Thuja orientalis treated albino mice (of both genders) with their respective control groups indicating a moderate effect of 50mg/ml solvent/Kg body weight of Thuja orientalis on the behavior of young albino mice.