Pharmacological effects of Azadirachta indica (neem) leaf extract on the ECG and blood pressure of rat
Koley, K.M.; Lal, J.
Indian Journal of Physiology and Pharmacology 38(3): 223-225
1994
ISSN/ISBN: 0019-5499 PMID: 7814089 Document Number: 435399
Neem leaf alcoholic extract (NLE) was investigated for its effects on the ECG and blood pressure of rat. Intravenous administration of NLE (100, 300 and 1000 mg/kg) resulted in initial bradycardia followed by cardiac arrhythmia in rats. NLE produced a significant and dose-related fall in blood pressure which was immediate, sharp and persistent. Pre-treatment with either atropine or mepyramine failed to prevent the hypotensive effect of NLE.