Vaccines as an approach to the immunocorrection in herpetic infections
Barinskiĭ, I.F.; Alimbarova, L.M.; Lazarenko, A.A.; Makhmudov, F.R.; Sergeev, O.V.
Voprosy Virusologii 59(1): 5-11
2014
ISSN/ISBN: 0507-4088 PMID: 25065139 Document Number: 677792
Development of vaccines for immunologic correction in herpetic infections is an important problem that raises a growing concern worldwide. The data on the experimental studies of the efficacy of an inactivated whole-virion vaccine against herpes simplex viruses types 1 and 2 (HSV-1 and -2) using an animal model are discussed. The results of the multiyear application of the vaccine to ophthalmology and dermatology practice are also presented. The results unambiguously show a high efficacy of the vaccine in the prevention of recurrences of the infections based on activation of specific T-cell response. A live vaccine against the varicella zoster virus (VZV) was developed for control of the infection in children. For the cytomegalovirus (CMV) infection in adults, inactivated whole-virion vaccines are at the stage of development. An important part of the study addresses a combined application of the inactivated vaccines with immunomodulators.