Anti glutamate-decarboxylase antibodies: a liaison between localisation related epilepsy, stiff-person syndrome and type-1 diabetes mellitus
Szűcs, A.; Barcs, G.áb.; Winkler, G.áb.; Soós, Z.; Folyovich, A.ás.; Kelemen, A.; Várallyay, P.ét.; Kamondi, A.
Ideggyogyaszati Szemle 67(7-8): 269-271
2014
ISSN/ISBN: 0019-1442 PMID: 25509368 Document Number: 677793
We present two patients with partial epilepsy, type-1 diabetes and stiff person syndrome associated with high serum auto-antibody levels to glutamate-decarboxylase (anti-GAD). Both patients were or have suffered from additional autoimmune conditions. The presence of stiff person syndrome and elevated anti-GAD levels have to make clinicians look for additional autoimmune conditions including type-1 diabetes. On the other hand, the co-morbidity of partial epilepsy with autoimmune conditions in patients with elevated serum anti-GAD suggests an autoimmune mechanism of partial epilepsy in these cases.