Tests of specific cellular and humoral immunity in herpetic infections of the eyes
Slepova, O.S.; Murav'eva, T.V.; Zaĭtseva, N.S.
Voprosy Virusologii 2: 196-200
1981
ISSN/ISBN: 0507-4088 PMID: 7023054 Document Number: 176613
The ratio of the values of lymphocyte blast transformation and leukocyte migration inhibition to the level of humoral antibodies, detection of HSV antigen in the eye and activity of the clinical process in the time course of disease was studied in 213 patients with ophthalmoherpes. The immunological markers characterizing the features of pathogenesis and prognosis of herpetic eye disease were determined. In the favourable course of ophthalmoherpes blast transformation of 5-10% and stable migration inhibition throughout the disease were observed. A decrease in the functional activity of lymphocytes determined in the blast transformation test with phytohemagglutinin, the lack of specific blast transformation and migration inhibition, as well as marked increase of blast formation (above 10-15%) are the factors aggravating the course of the disease. The infectious and infectious-allergic period in the course of ophthalmoherpes were identified. The infectious stage was characterized by changes in the values of both cellular and humoral immunity. In the infectious-allergic stage cellular immunity reactions prevail in the presence of stable humoral antibody levels.