Murine peritoneal neutrophil activation upon tungsten nanoparticles exposure in vivo
Martinova, E.A.; Baranov, V.I.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 2014(3): 73-75
2014
ISSN/ISBN: 0031-2991 PMID: 25536795 Document Number: 676053
Two examples of tungsten carbide nanoparticles (d = 15 nm, 50 nm) and tungsten carbide nanoparticles with 8% cobalt (d = 50 nm) have been found to induce the neutrophil activation 3 h and 36 h after intraperitoneal administration in the doses 0.005; 0.025; 0.05; 0.25; 0.5; 1; 2.5 and 5 microgram per 1 gram body weight to FVB mice. Neutrophil activation was calculated based on the CD11b and S100 antigen expression. Effect of nanoparticles is bimodal for all tested examples.