Study of the influence of gold nanoparticles on activation of human blood neutrophils
Chekanov, A.V.; Baranova, O.A.; Levin, A.D.; Solov'eva, É.Iu.; Fedin, A.I.; Kazarinov, K.D.
Biofizika 58(3): 495-500
2013
ISSN/ISBN: 0006-3029 PMID: 24159819 Document Number: 665998
Activation of neutrophils in the presence of gold nanoparticles is accompanied by the formation of free radical peroxidation products recording the flash of chemiluminescence. The basis for the activation mechanism has its origins most likely in the influence of the gold particles on the surface membrane potential of neutrophils. Investigation of changes in the fluorescence intensity of the negatively charged ANS probe on the surface of model membranes by adding different concentrations of gold nanoparticles indicates the change in the membrane surface charge density that can cause cell activation.