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Influence of the concentration of silver nanoparticles on the proliferation behavior of human umbilical vein endothelial cell and human umbilical artery smooth muscle cells

Shi, Q.; Wang, X.; Yu, W.; Huang, R.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 27(4): 875-881

2010

ISSN/ISBN: 1001-5515
PMID: 20842863
Document Number: 639171
The proliferation difference between Human Umbilical Vein Endothelial Cells (HUVEC) and Human Umbilical Artery Smooth Muscle Cells (HUASMC) in response to the concentration of silver nanoparticles was investigated via MTT, BCA and FCM tests. The obtained experimental data were statistically analyzed and discussed in order to know the causation of the proliferation difference. The results show there is significant difference in proliferation between HUVEC and HUASMC corresponding to the concentration of silver nanoparticles, and such difference can be attributed to the varied adhesion shape and apoptosis of the cells being influenced by nano-Ag content and Fetal bovine serum (FBS) content in culture medium.

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